Basic Information
| LncRNA/CircRNA Name | PCA3 |
| Synonyms | PCA3, DD3, NCRNA00019, PCAT3 |
| Region | GRCh38_9:76691980-76863307 |
| Ensemble | ENSG00000225937 |
| Refseq | NR_015342 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | cell lines (LNCaP, PC3, RWPE-1, PrEC etc.) |
| Expression Pattern | up-regulated |
| Function Description | PCA3 is a non-coding RNA (ncRNA) that is highly expressed in prostate cancer (PCa) cells, LNCaP siPCA3-transfected cells significantly inhibited cell growth and viability, and increased the proportion of cells in the sub G0/G1 phase of the cell cycle and the percentage of pyknotic nuclei, compared to those transfected with scramble siRNA (siSCr)-transfected cells. Our findings suggest that the ncRNA PCA3 is involved in the control of PCa cell survival, in part through modulating AR signaling, which may raise new possibilities of using PCA3 knockdown as an additional therapeutic strategy for PCa control. |
| Pubmed ID | 23130941 |
| Year | 2012 |
| Title | PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling. |
External Links
| Links for PCA3 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |