Basic Information
| LncRNA/CircRNA Name | PCA3 |
| Synonyms | PCA3, DD3, NCRNA00019, PCAT3 |
| Region | GRCh38_9:76691980-76863307 |
| Ensemble | ENSG00000225937 |
| Refseq | NR_015342 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | PCR etc. |
| Sample | prostate cancer tissues, blood (leukocytes) |
| Expression Pattern | up-regulated |
| Function Description | PCA3 TAAA STR polymorphisms and 8 genotypes were found in both peripheral blood leukocytes and prostate tissues, the carriers with more TAAA repeats were associated with increased risk for PCa than individuals having less TAAA repeats. Interestingly, 18 (15.0%) of 120 PCa patients had more (TAAA)n repeats in prostate tissues than that in peripheral blood leukocytes, and 3 (2.5%) of 120 had less (TAAA)n repeats in prostate tissues. Short tandem repeat polymorphism of TAAA in the promoter region of PCA3 gene is a risk-increasing factor for prostate cancer in the Chinese population. |
| Pubmed ID | 25445501 |
| Year | 2014 |
| Title | Long noncoding RNA PCA3 gene promoter region is related to the risk of prostate cancer on Chinese males. |
External Links
| Links for PCA3 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |