Basic Information
| LncRNA/CircRNA Name | PBB12 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | Luciferase assay, RT-PCR, Western blotting |
| Sample | OS cell lines MG63 (TCHu124) and SAOS-2 (TCHu114),293TN cells,OS tumors |
| Expression Pattern | up-regulated |
| Function Description | osteosarcoma patients with a high PBB12 level frequently showed increased metastasis.PBB12 can competitively bind to hsa-miR-204-5p by acting as a microRNA sponge.PBB12 intervenes in the Kruppel-like factor 4 (KLF4)/hsa-miR-204-5p/activating transcription factor 2 (ATF2) pathway and affects the proliferation and invasion of osteosarcoma cells.in the osteosarcoma cell lines MG63 and SAOS-2, PBB12 silencing and overexpression significantly increases or reversed the inhibitory effect of KLF4 on the proliferation and invasion of tumor cells, respectively. |
| Pubmed ID | 31894336 |
| Year | 2020 |
| Title | Mechanisms Underlying the Promotion of Osteosarcoma Cell Proliferation and Invasion by lncRNA PBB12 |
External Links
| Links for PBB12 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |