Basic Information
| LncRNA/CircRNA Name | PARTICLE |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NR_038942 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | cell lines (U2OS, SJSA, MG63) |
| Expression Pattern | down-regulated |
| Function Description | The long ncRNA PARTICLE (promoter of MAT2A antisense radiation-induced circulating long non-coding RNA) is transiently elevated in response to irradiation and influences epigenetic silencing modification within WWOX. It can be concluded that the lncRNA PARTICLE influences the WWOX tumor suppressor and in the absence of WWOX FRA16D breakage, it is associated with OS metastasis-free survival. |
| Pubmed ID | 29152092 |
| Year | 2017 |
| Title | The long non-coding RNA PARTICLE is associated with WWOX and the absence of FRA16D breakage in osteosarcoma patients. |
External Links
| Links for PARTICLE | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |