Basic Information
| LncRNA/CircRNA Name | PART1 |
| Synonyms | NA |
| Region | GRCh38_5:60487713-60547657 |
| Ensemble | ENSG00000152931 |
| Refseq | NR_024617 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, luciferase reporter assay |
| Sample | cell line (LoVo, SW620) |
| Expression Pattern | up-regulated |
| Function Description | In the present study, we revealed that prostrate androgen-regulated transcript1 (PART-1) was highly expressed in colorectal cancer cells and tissues , and knockdown of PART-1 suppressed cell proliferation and metastasis, both in vitro and in vivo. In addition, PART-1 functioned as a ceRNA of DNMT3A,by sponging miR-143. Finally, PART-1 induced tumor progression by regulating DNMT3A. The Kaplan-Meier log-rank test was used to compare survival curves.Several studies have reported that miR-143 could regulate tumor progression through direct interaction with DNMT3A. As an enzyme modulating DNA methylation, DNMT3A can exert diverse epigenetic regulations. |
| Pubmed ID | 28619512 |
| Year | 2017 |
| Title | PART-1 functions as a competitive endogenous RNA for promoting tumor progression by sponging miR-143 in colorectal cancer. |
External Links
| Links for PART1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |