Basic Information
| LncRNA/CircRNA Name | BCAR4 |
| Synonyms | NA |
| Region | GRCh38_16:11819829-11828845 |
| Ensemble | ENSG00000262117 |
| Refseq | NR_024049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | cervical cancer tissue, cell lines ((HeLa, SiHa, Caski, C4-1 and C-33A) |
| Expression Pattern | up-regulated |
| Function Description | BCAR4 expression was significantly up-regulated in cervical cancer tissue and cell lines. Moreover, patients with high BCAR4 expression showed worse survival outcomes and overexpression of BCAR4 might be an independent prognostic factor in cervical cancer. A significant association between BCAR4 expressionand clinicopathological factors such as tumor size (P = 0.0022),lymph node metastasis (P = 0.0100) and FIGO stage (P = 0.0007) was found in cervical cancer tissues. Furthermore, overexpression of BCAR4 remarkably promoted the proliferation, motility of cervical cancer cells and silencing BCAR4 significantly suppressed the proliferation, migration and invasion of cervical cancer cells. Additionally, overexpression of BCAR4 promoted epithelial-mesenchymal transition (EMT) process and silencing BCAR4 suppressed EMT process in cervical cancer cells. |
| Pubmed ID | 29937186 |
| Year | 2018 |
| Title | Up-regulated BCAR4 Contributes to Proliferation and Migration of Cervical Cancer Cells |
External Links
| Links for BCAR4 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |