Basic Information
| LncRNA/CircRNA Name | PART1 |
| Synonyms | prostate androgen-regulated transcript 1 |
| Region | GRCh38_5:60487713-60547657 |
| Ensemble | ENSG00000152931 |
| Refseq | NR_024617 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | luciferase assay, RIP, RT-PCR |
| Sample | tumor and adjacent nontumorous tissues,peripheral blood samples,HT29 and HCT116,two human colon adenocarcinoma cell lines,and HEK-293T cells |
| Expression Pattern | up-regulated |
| Function Description | compared with 10 healthy controls, the level of PART1 was increased, whereas miR-150-5p expression was diminished in the serum of 10 colorectal cancer patients. Cell proliferation and migration, along with epithelial-mesenchymal transition, was promoted by PART1 overexpression.lncRNA PART1 may regulate leucine-rich ?-2-glycoprotein-1 (LRG1) expression through a competing interaction mechanism that hindering miR-150-5p function. |
| Pubmed ID | 31898365 |
| Year | 2020 |
| Title | LncRNA PART1 Facilitates the Malignant Progression of Colorectal Cancer via miR-150-5p/LRG1 Axis |
External Links
| Links for PART1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |