Basic Information
| LncRNA/CircRNA Name | PAR5 |
| Synonyms | LPAR5, GPR92, GPR93, KPG_010, LPA5 |
| Region | GRCh38_15:24985053-24988232 |
| Ensemble | ENSG00000279192 |
| Refseq | NR_022008 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, Western blotting etc. |
| Sample | cell lines (U87, U251) |
| Expression Pattern | down-regulated |
| Function Description | PAR5 was signifcantly downregulated in glioma tissues and cell lines. Furthermore, PAR5 expression was negatively correlated with tumor size, World Health Organization (WHO) grade and Karnofsky performance score (KPS). Patients with low PAR5 expression in tumors had a worse overall survival compared to those with higher expression. Finally, in vitro restoration of PAR5 expression inhibited human glioma cell proliferation, invasion and migration by binding to EZH2 and regulating oncogene expression. This fnding may provide a therapeutic approach for the future treatment of glioma. |
| Pubmed ID | 29048683 |
| Year | 2017 |
| Title | Long non-coding RNA PAR5 inhibits the proliferation and progression of glioma through interaction with EZH2 |
External Links
| Links for PAR5 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |