Basic Information
| LncRNA/CircRNA Name | PAPAS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | RT-qPCR, Western blot analysis etc. |
| Sample | fasting blood ,OSCC cell lines(SCC090 and SCC25 ) |
| Expression Pattern | up-regulated |
| Function Description | Plasma PAPAS and transforming growth factor ?1 (TGF-?1) were both upregulated in patients with OSCC, and were positively correlated only in patients with OSCC.Plasma levels of PAPAS were not significantly affected by AJCC stages and upregulation of PAPAS distinguished stage I OSCC patients from healthy controls. High plasma levels of PAPAS were followed by low overall survival rate.PAPAS overexpression led to upregulation of TGF-?1 in OSCC cells, while TGF-?1 treatment failed to significantly affect PAPAS. PAPAS overexpression and exogenous TGF-?1 treatment led to promoted invasion and migration of OSCC cells. In addition, TGF-? inhibitor attenuated the effects of PAPAS overexpression. |
| Pubmed ID | 31099126 |
| Year | 2019 |
| Title | LncRNA PAPAS Promotes Oral Squamous Cell Carcinoma by Upregulating Transforming Growth factor-?1 |
External Links
| Links for PAPAS | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |