Basic Information
| LncRNA/CircRNA Name | PANDAR |
| Synonyms | PANDAR, PANDA |
| Region | GRCh38_6:36673621-36675126 |
| Ensemble | ENSG00000281450 |
| Refseq | NR_109836 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (SW480, LoVo, HCT-116, SW620, HT29) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of PANDAR was higher in CRC tissues and cells. Patients with high PANDAR expression level had poorer overall survival than those with low PANDAR expression. Knockdown of PANDAR could inhibit cell growth, migration and invasion, arrest cell cycle as well as induce apoptosis of CRC cells in vitro study. In addition, PANDAR could affect epithelial-mesenchymal transition through inhibiting N-cadherin, vimentin, B-catenin, Snail and Twist expression and increasing the expression levels of E-cadherin. |
| Pubmed ID | 27629879 |
| Year | 2016 |
| Title | The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer and promotes metastasis by EMT pathway. |
External Links
| Links for PANDAR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |