Basic Information
LncRNA/CircRNA Name | PANDAR |
Synonyms | PANDAR, PANDA |
Region | GRCh38_6:36673621-36675126 |
Ensemble | ENSG00000281450 |
Refseq | NR_109836 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | bladder cancer |
ICD-0-3 | C67 |
Methods | qPCR, RNAi, Flow cytometry assay etc. |
Sample | bladder cancer tissues, cell lines (5637, SW780, UMUC3, T24 and SV-HUC-1 etc.) |
Expression Pattern | up-regulated |
Function Description | We found that PANDAR was significantly up-regulated in bladder cancer tissues compared with paired-adjacent nontumorous tissues in a cohort of 55 bladder cancer patients. Moreover, increased PANDAR expression was positively correlated with higher histological grade and advanced TNM stage. Further experiments demonstrated that inhibited cell proliferation/migration and induced apoptosis by silencing PANDAR were also observed in bladder cancer cells. Furthermore, over expression of PANDAR in bladder cancer cells promoted the proliferation/migration and suppressed apoptosis. |
Pubmed ID | 27206339 |
Year | 2016 |
Title | Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer. |
External Links
Links for PANDAR | GenBank HGNC NONCODE |
Links for bladder cancer | OMIM COSMIC |