Basic Information
| LncRNA/CircRNA Name | PANDAR |
| Synonyms | NA |
| Region | GRCh38_6:36673621-36675126 |
| Ensemble | ENSG00000281450 |
| Refseq | NR_109836 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | breast cancer tissues and adjacent normal tissues, breast cancer cell lines(MCF-7, MDAMB-231, MDA-MB-436, SK-BR-3 cells) and the normal mammary epithelial cell line (MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | PANDAR expression was higher in breast cancer tissues and cells compared with adjacent normal tissues and the normal mammary epithelial cell line, respectively. Higher lncRNA PANDAR expression positively associated with lymph node metastasis and advanced clinical stage in patients. In vitro,knockdown of lncRNA PANDAR significantly suppressed cell proliferation, cell colony formation and cell invasion ability in breast cells. Furthermore, knockdown of lncRNA PANDAR dramatically inhibited cell epithelial-mesenchymal transition (EMT) pathway by downregulating Vimentin, MMP2 and MMP9 expression, but upregulating E-cadherin expression in breast cancer. |
| Pubmed ID | 31104011 |
| Year | 2019 |
| Title | bition of lncRNA PANDAR Reduces Cell Proliferation, Cell Invasion and Suppresses EMT Pathway in Breast Cancer |
External Links
| Links for PANDAR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |