Basic Information
| LncRNA/CircRNA Name | PANDAR |
| Synonyms | NA |
| Region | GRCh38_6:36673621-36675126 |
| Ensemble | ENSG00000281450 |
| Refseq | NR_109836 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | melanoma tissues, cell lines (CHL-1, A375, SK-MEL-1, WM-35, and WM-115) |
| Expression Pattern | up-regulated |
| Function Description | The PANDAR expression is strikingly upregulated in melanoma tissues compared with paired-adjacent non-tumorous tissues and elevated PANDAR is positively correlated with short overall survival time. PANDAR expression levels negatively correlated with tumor growth and metastasis. The results also demonstrate that knockdown of PANDAR inhibits cell viability, migration, invasion, tumorigenesis, and EMT, whereas overexpression of PANDAR gave opposite results by promoting cell viability, proliferation, migration, invasion, tumorigenesis, and EMT of melanoma cells. These new findings all illustrate that PANDAR might play a pivotal oncogenic role in the occurrence and development of melanoma, and PANDAR might promote melanoma cell invasion through regulating EMT, providing a potential diagnostic and therapeutic target for melanoma. |
| Pubmed ID | 31938355 |
| Year | 2018 |
| Title | Long Non-Coding RNA PANDAR Promotes Melanoma Cell Invasion Through Regulating Epithelial-Mesenchymal Transition |
External Links
| Links for PANDAR | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |