Basic Information
| LncRNA/CircRNA Name | pancEts-1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP etc. |
| Sample | cell lines (NB-1643, SK-N-BE(2), NB-1691, IMR32, BE(2)-CSK-N-AS, SH-SY5Y, and SK-N-SH), NB tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA pancEts-1 promoted the growth, invasion, and metastasis of neuroblastoma cells in vitro and in vivo Mechanistically, pancEts-1 bound to hnRNPK to facilitate its physical interaction with B-catenin, whereas hnRNPK stabilized the B-catenin by inhibiting proteasome-mediated degradation, resulting in transcriptional alteration of target genes associated with neuroblastoma progression. Both pancEts-1 and hnRNPK were upregulated in clinical neuroblastoma tissues, and were associated with unfavorable outcome of patients. |
| Pubmed ID | 29311158 |
| Year | 2018 |
| Title | Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated B-Catenin Stabilization. |
External Links
| Links for pancEts-1 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |