Basic Information
| LncRNA/CircRNA Name | PACER |
| Synonyms | PACERR, PACER, PTGS2-AS1 |
| Region | GRCh38_1:186680622-186681446 |
| Ensemble | ENSG00000273129 |
| Refseq | NR_125801 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | osteosarcoma tissues, cell lines (143B, MG63, Saos-2, U2OS, hFOB1.19) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that PACER was overexpressed in osteosarcoma tissues and cell lines compared with normal tissues and osteoblasts, respectively. PACER knockdown inhibited the proliferation and invasion of human osteosarcoma cells. Downregulation of PACER significantly suppressed the expression of COX-2, and the effects of PACER on cell proliferation and invasion were rescued by COX-2 overexpression. |
| Pubmed ID | 26476537 |
| Year | 2016 |
| Title | P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene. |
External Links
| Links for PACER | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |