Basic Information
| LncRNA/CircRNA Name | OR3A4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | NSCLC cell lines (H1299, SPCA1, PC-9 and A549), normal human bronchial epithelial cell line (16HBE), NSCLC tissues, adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | OR3A4 expression was remarkably upregulated in NSCLC tissues when compared with adjacent normal tissues. The overall survival of NSCLC patients in high OR3A4 expression group was significantly worse than those in low OR3A4 expression group. After the silence of OR3A4, the proliferation of NSCLC cells was significantly inhibited. Besides, the apoptosis of NSCLC cells was remarkably promoted after the silence of OR3A4. Meanwhile, knockdown of OR3A4 significantly down-regulated the mRNA and protein levels of SOX4 in NSCLC cells. Furthermore, the expression of SOX4 was found upregulated in both NSCLC tissues and cells. |
| Pubmed ID | 31378892 |
| Year | 2019 |
| Title | Long non-coding RNA OR3A4 is associated with poor prognosis of human non small cell lung cancer and regulates cell proliferation via up-regulating SOX4 |
External Links
| Links for OR3A4 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |