Basic Information
| LncRNA/CircRNA Name | OR3A4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | cell lines(A549/DDP,A549 ) |
| Expression Pattern | up-regulated |
| Function Description | Compared with OR3A4 expression of paired A549 cells, OR3A4 expression of A549/DDP cells was higher.Moreover, the functional assay showed that after OR3A4 was silenced in A549/DDP cells, cell cycle arrest and cell apoptosis was induced, and resistance to cisplatin was reversed.CDK1 expression was suppressed in A549/DDP cells by knockdown of OR3A4.OR3A4 participates in regulating cell cycle,cell apoptosis of NSCLC cells and the resistance to cisplatin via upregulating CDK1. |
| Pubmed ID | 31173293 |
| Year | 2019 |
| Title | Long Noncoding RNA OR3A4 Promotes Cisplatin Resistance of Non-Small Cell Lung Cancer by Upregulating CDK1 |
External Links
| Links for OR3A4 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |