Basic Information
| LncRNA/CircRNA Name | OLC8 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | GES-1, BGC-823, AGS, MKN1, MGC-803, and SGC-7901 cells, GC samples and normal adjacent tissues |
| Expression Pattern | up-regulated |
| Function Description | a novel lncRNA termed OLC8. OLC8 was significantly overexpressed in gastric cancer specimens and cell lines. In vitro experiments showed that OLC8 facilitated migration and viability of MKN1 and AGS cells. As expected, in vivo experiments also confirmed an oncogenic role for OLC8. Mechanistic study indicated that OLC8 associated with IL-11 transcripts. The OLC8-IL-11 binding greatly impaired the degradation of IL-11 mRNAs. Not surpris- ingly, enhanced expression of IL-11 could increase STAT3 activation to favor gastric cancer development. |
| Pubmed ID | 31273847 |
| Year | 2019 |
| Title | The long non-coding RNA OLC8 enhances gastric cancer by interaction with IL-11 |
External Links
| Links for OLC8 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |