Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | OIP5-AS1, cyrano, linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | hepatoblastoma tissues, cell lines (HepG2, HuH-6, SMMC-7721, QSG-7701 and L-02) |
| Expression Pattern | up-regulated |
| Function Description | OIP5-AS1 was oncogenic in hepatoblastoma for the high expression of it in hepatoblastoma tissues and cells. OIP5-AS1 knockdown was carried out in cancer cells.Unsurprisingly,this action was verified to be able to inhibit cell proliferation, metastasis and EMT progress in hepatoblastoma.We discovered OIP5-AS1 is located in nucleus of cancerous cells.It could target to miR-186a-5p and up-regulate the target gene of miR-186a-5p (ZEB1).Based on all above findings,we came into a conclusion that OIP5-AS1 is a ceRNA in Hepatoblastoma cells through modulating miR-186a-5p/ZEB1. |
| Pubmed ID | 29475118 |
| Year | 2018 |
| Title | Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1. |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for hepatoblastoma | OMIM COSMIC |