Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | Bladder cancer tissue, bladder cancer cell lines (SW780, J82, T24, and RT4) and normal bladder epithelial cell line (SV-HUC-1). SW780, J82, T24, and RT4 cells |
| Expression Pattern | up-regulated |
| Function Description | OIP5 AS1 was overexpressed in bladder cancer, and associated with clinical progression and short overall survival. The loss of function studies suggested downregulation of OIP5 AS1 expression decreased cell viability, induced cell cycle arrest and promoted cell apoptosis in bladder cancer. There was a positive association between OIP5 AS1 expression and OIP5 expression in bladder cancer tissues. Moreover, downregulation of OIP5 AS1 expression reduced messenger RNA and protein levels of OIP5 in bladder cancer cell lines. |
| Pubmed ID | 30485498 |
| Year | 2018 |
| Title | LncRNA OIP5-AS1 predicts poor prognosis and regulates cell proliferation and apoptosis in bladder cancer |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |