Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | OIP5-AS1, cyrano, linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, other |
| Sample | cervical cancer tissues and cell lines (HeLa, SiHa, and CasKi) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA OIP5-AS1 is demonstrated to mediate the physiological process of cervical cancer cells. Moreover, silencing SMAD3 via siRNA suppressed cell number, viability, migration and invasion, whereas overexpression of OIP5-AS1 promoted these abilities. Furthermore, lncRNA OIP5-AS1 exert its function via sponging miR-143-3p to regulate SMAD3 expression. |
| Pubmed ID | 30341904 |
| Year | 2019 |
| Title | Long Noncoding RNA OPA-interacting Protein 5 Antisense Transcript 1 Upregulated SMAD3 Expression to Contribute to Metastasis of Cervical Cancer by Sponging miR-143-3p |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |