Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | Opa-interacting protein 5 antisense transcript 1 |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | western blot, RT-qPCR, Luciferase reporter assay, RIP |
| Sample | C33As cells |
| Expression Pattern | up-regulated |
| Function Description | lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies. OIP5-AS1 depletion inhibited cell proliferation and promoted cell apoptosis in cervical cancer cells. Furthermore, we clarified that ROCK1 was the downstream effector of OIP5-AS1 and OIP5-AS1 acted as a molecular sponge of miR-143-3p. |
| Pubmed ID | 31939597 |
| Year | 2020 |
| Title | lncRNA OIP5-AS1 Targets ROCK1 to Promote Cell Proliferation and Inhibit Cell Apoptosis Through a Mechanism Involving miR-143-3p in Cervical Cancer |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |