Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, luciferase reporter assay etc |
| Sample | GC Tissues, cell lines(BeNa,GC9811-P,GES-1) |
| Expression Pattern | up-regulated |
| Function Description | OIP5-AS1 and ZBTB2 were strongly higher in GC tissues than noncancerous samples. OIP5-AS1 silencing remarkably curbed cell proliferation, migration and invasion, and elevated cell apoptosis in both AGS and MKN45 cells. Functional analysis indicated that OIP5-AS1 regulated ZBTB2 expression via binding to miR-153-3p. |
| Pubmed ID | 32196594 |
| Year | 2020 |
| Title | OIP5-AS1 Promotes the Progression of Gastric Cancer Cells via the miR-153-3p/ZBTB2 Axis |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |