Basic Information
| LncRNA/CircRNA Name | OGFRP1 |
| Synonyms | NA |
| Region | GRCh38_22:42269753-42275196 |
| Ensemble | ENSG00000182057 |
| Refseq | NR_036498 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Western blot assays, qPCR |
| Sample | Hep3B and HepG2 cells |
| Expression Pattern | up-regulated |
| Function Description | Cell proliferation of Hep3B was significantly inhibited by down-regulation of lncRNA OGFRP1 (P<0.05).Cell migration and invasion of Hep3B were also significantly inhibited by down-regulation of lncRNA OGFRP1. Wnt/B-catenin signaling pathway, involved in epithelial-mesenchymal transition (EMT), was inactivated by lncRNA OGFRP1 downregulation, including decreased expression of Wnt3a, B-catenin, N-cadherin and vimentin and increased expression of E-cadherin.the inhibitory effect of lncRNA OGFRP1 knockdown on Hep3B was mediated by the AKT/mTOR signaling pathway and IGF-1, an AKT signaling activator, could rescue the cellular phenotype. However, knockdown of lncRNA OGFRP1 did not influence cell proliferation, migration and invasion in HepG2 cells. |
| Pubmed ID | 29997441 |
| Year | 2018 |
| Title | Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/?-catenin signaling pathways. |
External Links
| Links for OGFRP1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |