Basic Information
| LncRNA/CircRNA Name | OGFRP1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, RNAi, other |
| Sample | NSCLC tissues and cell lines (H1299, SPC-A1, A549, H1975,HCC827) |
| Expression Pattern | up-regulated |
| Function Description | OGFRP1 expression was significantly up-regulated in both NSCLC tissues and cell lines, and the upregulation of OGFRP1 expression is a powerful predictor of advanced clinical stage, lymph nodes metastasis and poor prognosis for NSCLC patients. Loss-of-function assay indicated that knockdown of OGFRP1 inhibited proliferation, migration and invasion, and induced apoptosis in vitro. Mechanistically, OGFRP1 could directly bind to miR-124-3p and effectively act as a competing endogenous RNA (ceRNA) for miR-124-3p to promote the expression of the target gene LYPD3. |
| Pubmed ID | 30274775 |
| Year | 2018 |
| Title | Long Non-Coding RNA OGFRP1 Regulates LYPD3 Expression by Sponging miR-124-3p and Promotes Non-Small Cell Lung Cancer Progression |
External Links
| Links for OGFRP1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |