Basic Information
| LncRNA/CircRNA Name | OGFRP1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | endometrial cancer tissues and matched normal endometrial tissues , human endometrial cancer cell lines(HHUA, KLE,Ishikawa, and ECC-1) and normal endometrium (NE) cells |
| Expression Pattern | up-regulated |
| Function Description | OGFRP1 was up-regulated in endometrial cancer tissues and cells. OGFRP1 suppression inhibited the malignant behaviour (inhibited cell viability, promoted cell apoptosis, and suppressed cell migration and invasion) of the Ishikawa cells via negatively regulating miR-124-3p. SIRT1 was a target gene of miR-124-3p, and miR-124-3p regulated tumour growth and metastasis by the down-stream signal of SIRT1. Moreover, suppression of OGFRP1 restrained the activation of PI3K/AKT/GSK-3? signals in the Ishikawa cells via miR-124-3p/SIRT1 axis. |
| Pubmed ID | 31131636 |
| Year | 2019 |
| Title | Upregulation of Long Non-Coding RNA OGFRP1 Facilitates Endometrial Cancer by Regulating miR-124-3p/SIRT1 Axis and by Activating PI3K/AKT/GSK-3? Pathway |
External Links
| Links for OGFRP1 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |