Basic Information
| LncRNA/CircRNA Name | OECC |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, other |
| Sample | lung cancer tissues and cell lines (H1975, SPC-A-1) |
| Expression Pattern | up-regulated |
| Function Description | RNA-sequence analysis suggested that the phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin signaling pathway was positively regulated by OECC in lung cancer cells A549. In addition, overexpression of Akt in OECC-depleted A549 and 95D cells reversed the suppression of proliferation and migration caused by OECC depletion. The results of the present study identified lncRNA OECC as a novel regulator of lung cancer progression and provided new clues for the clinical treatment of lung cancer. |
| Pubmed ID | 31452780 |
| Year | 2019 |
| Title | Long Non-Coding RNA OECC Promotes Cell Proliferation and Metastasis Through the PI3K/Akt/mTOR Signaling Pathway in Human Lung Cancer |
External Links
| Links for OECC | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |