Basic Information
| LncRNA/CircRNA Name | OECC |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, luciferase reporter assay |
| Sample | colorectal cancer tissues, cell lines (SW620, HCT116, SW480, HT29, Caco-2, NCM460) |
| Expression Pattern | up-regulated |
| Function Description | We identified a novel lncRNA OECC, originating from chromosome 8q24 that is highly expressed in CRC tissues and cell lines and has a positive correlation with liver metastasis. Attenuation of lncRNA OECC expression prohibited CRC cell proliferation, induced apoptosis, and inhibited migration. lncRNA OECC is a direct target of miR-143-3p, enhancement of the epithelium marker E-cadherin was observed, while the expression of the mesenchymal marker Vimentin was inhibited with suppression of OECC expression. |
| Pubmed ID | 30126634 |
| Year | 2018 |
| Title | A novel long noncoding RNA OECC promotes colorectal cancer development and is negatively regulated by miR-143-3p. |
External Links
| Links for OECC | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |