Basic Information
| LncRNA/CircRNA Name | NRON |
| Synonyms | NRON??CRNA00194 |
| Region | GRCh38_9:126408041-126408410 |
| Ensemble | ENSG00000253079 |
| Refseq | NR_045006 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR etc. |
| Sample | All TNBC and adjacent non-cancer tissue, Hs 578T (Sigma-Aldrich, USA) and BT-549 (ATCC, USA) two cell lines |
| Expression Pattern | down-regulated |
| Function Description | The down-regulation of NRON in triple-negative breast cancer (TNBC) tissues compared with paired adjacent healthy tissues. In contrast, lncRNA snaR was up-regulated in TNBC tissues and was inversely correlated with NRON. Expression levels of snaR increased, while expression levels of NRON decreased along with the increase of clinical stages. The snaR overexpression resulted in promoted cancer cell proliferation but did not significantly affect NRON expression. NRON overexpression inhibited cancer cell proliferation and down-regulated snaR. The snaR overexpression reduced the effects of NRON overexpression. |
| Pubmed ID | 30996114 |
| Year | 2019 |
| Title | LncRNA NRON Down-Regulates lncRNA snaR and Inhibits Cancer Cell Proliferation in TNBC |
External Links
| Links for NRON | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |