Basic Information
| LncRNA/CircRNA Name | NRON |
| Synonyms | NRON??CRNA00194 |
| Region | GRCh38_9:126408041-126408410 |
| Ensemble | ENSG00000253079 |
| Refseq | NR_045006 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot etc |
| Sample | BC tissues, cell lines(J82, 5637, T24, UMUC3, SW780) |
| Expression Pattern | up-regulated |
| Function Description | The expression of NRON was significantly upregulated in BC specimens and cell lines compared with paired adjacent normal tissues and normal cell lines. The upregulation of NRON in bladder cancer patients was significantly associated with the depth of bladder tumor invasion and poor prognosis. Knockdown of NRON inhibited BC cells proliferation, migration, invasion and tumorigenicity. Furthermore, NRON promoted epithelial-mesenchymal transition (EMT) progression, and NRON-induced EZH2 expression contributed to this process. Conclusion: In conclusion, our results suggested that NRON acted as an oncogene and tumor biomarker for BC. |
| Pubmed ID | 32194786 |
| Year | 2020 |
| Title | LncRNA NRON Promotes the Proliferation, Metastasis and EMT Process in Bladder Cancer |
External Links
| Links for NRON | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |