Basic Information
| LncRNA/CircRNA Name | NR2F2-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:96110040-96327361 |
| Ensemble | ENSG00000247809 |
| Refseq | XR_109225 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | NSCLC tissue, lung cancer cell lines including A549, H460, H1299, SPC-A-1, Calu-3 and H1650 cells, normal human bronchial epithelial (NHBE) cell line |
| Expression Pattern | up-regulated |
| Function Description | elevated expression of NR2F2 AS1 was detected in NSCLC tissues and cells and was remarkably associated with the tumor, node, metastasis (TNM) stage and the status of lymphatic metastasis of patients. Down regulated NR2F2 AS1 contributed to the promotion of cell apoptosis and the inhibition of cell proliferation and invasion in A549 and SPC A 1 cells in vivo and vitro. Through bioinformatics analysis, NR2F2 AS1 functions as a ceRNA directly binding to miR 320b, BMI1 was a direct target of miR 320b. Combined with the following cellular experiments, the data showed that NR2F2 AS1 may influence the NSCLC cell proliferation, invasion and apoptosis through regulating miR 320b targeting BMI1. |
| Pubmed ID | 30592135 |
| Year | 2019 |
| Title | LncRNA NR2F2-AS1 promotes tumourigenesis through modulating BMI1 expression by targeting miR-320b in non-small cell lung cancer |
External Links
| Links for NR2F2-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |