Basic Information
| LncRNA/CircRNA Name | NR2F2-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:96110040-96327361 |
| Ensemble | ENSG00000247809 |
| Refseq | XR_109225 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR , Western blot etc. |
| Sample | PC tissue and adjacent tissues ,22Rv1 human PC cell line (ATCC) |
| Expression Pattern | up-regulated |
| Function Description | NR2F2-AS1 was upregulated in PC and positively correlated with CDK4. In PC cells, NR2F2-AS1 overexpression led to upregulated, while NR2F2-AS1 siRNA silencing led to downregulated CDK4.High levels of NR2F2-AS1 and CDK4 in PC tissues were closely correlated with the poor survival of PC patients. NR2F2-AS1 overexpression led to increased, while NR2F2-AS1 siRNA silencing led to proliferation rate of PC cells. Moreover, NR2F2-AS1 also showed positive effects on cell cycle progression. In addition, CDK4 overexpression reduced the effects of NR2F2-AS1 siRNA silencing. Therefore, NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in PC. |
| Pubmed ID | 31566058 |
| Year | 2019 |
| Title | LncRNA NR2F2-AS1 Positively Regulates CDK4 to Promote Cancer Cell Proliferation in Prostate Carcinoma |
External Links
| Links for NR2F2-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |