Basic Information
| LncRNA/CircRNA Name | NR-104098 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | cell lines (NB4 and THP-1) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA NR-104098 is a suppressor gene that is significantly upregulated in AML cells.LncRNA NR-104098 could inhibit proliferation and induce differentiation in AML cells in vitro and also play main role in the mouse xenografts. Mechanically, it was confirmed that lncRNA NR-104098 may effectively inhibit EZH2 transcription by directly binding to E2F1 and recruiting E2F1 to the EZH2 promoter. |
| Pubmed ID | 32296698 |
| Year | 2020 |
| Title | LncRNA NR-104098 Inhibits AML Proliferation and Induces Differentiation Through Repressing EZH2 Transcription by Interacting With E2F1. |
External Links
| Links for NR-104098 | GenBank HGNC NONCODE |
| Links for acute lymphoblastic leukemia | OMIM COSMIC |