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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Western blot
Sample	Human gastric carcinoma cell lines (including AGS, BGC-823, SGC-7901) and normal immortalized gastric mucosal epithelial cell line (GES-1), gastric carcinoma and para-carcinoma tissue
Expression Pattern	up-regulated
Function Description	QRT-PCR results showed that the expression level of NR027113 in gastric carcinoma tissues was significantly higher than that of para-carcinoma tissues. Compared with patients with low expression of NR027113, the incidence of lymph node metastasis and distant metastasis was significantly higher in patients with high NR027113 expression. Meanwhile, the survival rate of patients with low NR027113 expression was significantly lower. Compared with control group, the invasion and migration abilities of cells in NR027113 knockdown group were significantly decreased. Subsequent qRT-PCR results demonstrated that the expression of EMT signaling pathway-related proteins was significantly changed after transfection of sh-NR027113. The above finding indicated that NR027113 could inhibit the malignant progression of gastric carcinoma. Moreover, the addition of transforming growth factor-? (TGF-?) cytokines synergistically promoted the malignant progression of gastric carcinoma with NR027113.
Pubmed ID	31210301
Year	2019
Title	LncRNA NR027113 promotes malignant progression of gastric carcinoma via EMT signaling pathway

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