Basic Information
| LncRNA/CircRNA Name | NR027113 |
| Synonyms | PHACTR2-AS1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, other |
| Sample | HCC tissue and cell lines((Bel-7402, SK-HEP-1,PLC/PRF/5, MHCC97H, and SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | HCC patients with higher NR027113 expression were associated with significantly shorter overall survival and disease-free survival. NR027113 knockdown inhibited the proliferation and metastasis of HCC cells in vitro. In addition, NR027113 knock-down was found to inhibit the activity of the PI3K/Akt signaling pathway and restrain the EMT process. Furthermore, we found that PTEN silencing could reverse the inhibitory effect of NR027113 knockdown on Akt phosphorylation and HCC cells function. |
| Pubmed ID | 30468465 |
| Year | 2018 |
| Title | Down-regulation of LncRNA NR027113 Inhibits Cell Proliferation and Metastasis via PTEN/PI3K/AKT Signaling Pathway in Hepatocellular Carcinoma |
External Links
| Links for NR027113 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |