Basic Information
| LncRNA/CircRNA Name | NORAD |
| Synonyms | NORAD, LINC00657, ASHGA5P032173 |
| Region | GRCh38_20:36045622-36050960 |
| Ensemble | ENSG00000260032 |
| Refseq | NR_027451 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | Gastric Cancer tissues and cell lines(MKN28, MKN45,SGC7901, SNU-16 ) |
| Expression Pattern | up-regulated |
| Function Description | Mechanistically, NORAD acted as a competitive endogenous RNA (ceRNA), which sponged miR-608 and suppressed the expression of miR-608 in gastric cancer cells. Further experiments demonstrated that miR-608 targeted the forkhead box O6 (FOXO6) and negatively regulated the expression of FOXO6. Consistent with the inhibitory effect of NORAD on miR-608, overexpression of NORAD enhanced the level of FOXO6 in gastric cancer cells. |
| Pubmed ID | 30453063 |
| Year | 2019 |
| Title | The Long Noncoding RNA NORAD Promotes the Growth of Gastric Cancer Cells by Sponging miR-608 |
External Links
| Links for NORAD | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |