Basic Information
| LncRNA/CircRNA Name | NORAD |
| Synonyms | NA |
| Region | GRCh38_20:36045622-36050960 |
| Ensemble | ENSG00000260032 |
| Refseq | NR_027451 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | tumor bone tissues and adjacent nontumor bone tissues ,human osteosarcoma cell lines(Saos-2, 143B, HOS, KHOS/240S, MG-63, U-2OS, SK-ES-, and Hs755(B)) ,human nontumor osteoblast cell line(hFOB1.19) |
| Expression Pattern | up-regulated |
| Function Description | NORAD was found to be significantly overexpressed in both osteosarcoma cells and osteosarcoma tumors.In Saos-2 and 143B cells transfected with NORAD-specific siRNA, their proliferation, invasion, and in vivo explant growth were all markedly suppressed.Hsa-miR-199a-3p was confirmed to be the competing target of NORAD.Its downregulation in Saos-2 and 143B cells inversely augment proliferation and invasion that were initially suppressed by NORAD-downregulation. |
| Pubmed ID | 31169973 |
| Year | 2019 |
| Title | Long Noncoding RNA NORAD Regulates Cancer Cell Proliferation and Migration in Human Osteosarcoma by Endogenously Competing With miR-199a-3p |
External Links
| Links for NORAD | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |