Basic Information
| LncRNA/CircRNA Name | NONHSAT105177 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Melittin | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic Ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, Western blot, Microarray, other |
| Sample | PDAC tissues and cell lines (SW1990,Capan1, PATU8988, HS766T, BXPC3, and Panc1) |
| Expression Pattern | up-regulated |
| Function Description | Of these lncRNAs, we focused on the lncRNA NONHSAT105177, which had about a 22-fold increase in expression with melittin treatment. We found that melittin treatment increased NONHSAT105177 expression in PDAC cell lines but not in normal pancreatic ductal epithelial cell line. NONHSAT105177 expression was significantly lower in PDAC cancer tissues than in adjacent noncancerous tissues. Additionally, overexpression of NONHSAT105177 inhibited PDAC cell proliferation, migration, and the epithelial-mesenchymal transition (EMT), both in vitro and in vivo. Consistent with the mechanism of action of melittin, NONHSAT105177 significantly downregulated cholesterol pathway genes, including Clusterin (CLU). Moreover, we found that NONHSAT105177 trafficking was mediated by exosomes. |
| Pubmed ID | 30237397 |
| Year | 2018 |
| Title | Melittin-induced Long Non-Coding RNA NONHSAT105177 Inhibits Proliferation and Migration of Pancreatic Ductal Adenocarcinoma |
External Links
| Links for NONHSAT105177 | GenBank HGNC NONCODE |
| Links for pancreatic Ductal adenocarcinoma | OMIM COSMIC |