Basic Information
| LncRNA/CircRNA Name | NONHSAT062994 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot etc. |
| Sample | CRC tissues, cell lines (SW620, LS174T, SW480, DLD-1, RKO, HCT116, and LoVo) |
| Expression Pattern | down-regulated |
| Function Description | We here reported that NONHSAT062994 was significantly downregulated in human CRC tissues and cell lines. Moreover, its expression was inversely correlated with tumor size and overall survival (OS) time in CRC patients. In CRC cells, the overexpression and knockdown of NONHSAT062994 inhibited and enhanced CRC cell growth, respectively, in vitro and in vivo. Mechanistically, NONHSAT062994 functioned as a tumor suppressor to inhibit CRC cell growth by inactivating Akt signaling. Notably, the NONHSAT062994 expression status was negatively correlated with the Akt downstream targets c-Myc and Cyclin D1 in clinical CRC samples. |
| Pubmed ID | 28978149 |
| Year | 2017 |
| Title | The long non-coding RNA NONHSAT062994 inhibits colorectal cancer by inactivating Akt signaling. |
External Links
| Links for NONHSAT062994 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |