Basic Information
| LncRNA/CircRNA Name | NONHSAG016418 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (L02, SMMC7721, Bel7404, Huh7 and PLC/PRF/8) |
| Expression Pattern | up-regulated |
| Function Description | mRNA,miRNA and lncRNA regulatory or co-expression networks were constructed.From the construction of the regulatory networks,five miRNAs and ten lncRNAs were identified as key differ entially expressed noncoding RNAs associated with HCC progression.Finally, the regulatory effects of ten lncRNAs and miRNAs were validated. The study provides a novel insight into the understanding of the transcriptional regulation of HCC,and differentially expressed lncRNAs targeted and regulated by miRNAs were identified and validated in HCC specimens and cell lines.Following transfection of miRNAs,the majority of the upregulated lncRNAs altered their expression levels as predicted,and were downregulated compared with negative control(NC). |
| Pubmed ID | 29512731 |
| Year | 2018 |
| Title | The mRNA, miRNA and lncRNA networks in hepatocellular carcinoma: An integrative transcriptomic analysis from Gene Expression Omnibus |
External Links
| Links for NONHSAG016418 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |