Basic Information
| LncRNA/CircRNA Name | NNT-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:43571594-43603230 |
| Ensemble | ENSG00000248092 |
| Refseq | NR_073113 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | CRC tissues, cell lines (SW480 and SW620) |
| Expression Pattern | up-regulated |
| Function Description | NNT-AS1 was expressed higher in tumor tissues than that in adjacent noncancer tissues, and higher expression of NNT-AS1 was significantly correlated with lymph node metastasis, TNM stage, vessel invasion and differentiation. Knockdown of NNT-AS1 significantly impaired CRC cell proliferation, migration and invasion in vitro and silencing NNT-AS1 also suppressed tumor growth and metastasis in nude mice. The western blot experiments revealed that silencing NNT-AS1 inhibited epithelial-mesenchymal transition (EMT) and inactivated MAPK/Erk signaling pathway in CRC cell lines. |
| Pubmed ID | 27966450 |
| Year | 2017 |
| Title | Upregulated NNT-AS1, a long noncoding RNA, contributes to proliferation and migration of colorectal cancer cells in vitro and in vivo. |
External Links
| Links for NNT-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |