Basic Information
| LncRNA/CircRNA Name | NLC1-C |
| Synonyms | PICSAR, C21orf113, LINC00162, NCRNA00162, NLC1-C, NLC1C, PRED74 |
| Region | GRCh38_21:44999208-45004727 |
| Ensemble | ENSG00000275874 |
| Refseq | NR_024089 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | testicular embryonal carcinoma |
| ICD-0-3 | C62 |
| Methods | Microarray, qPCR, RNAi, Western blot, Northern blot, RIP, RNA pull-down assay etc. |
| Sample | testicular tissues, cell lines (NTERA-2, NCCIT, HEK293 T cell) |
| Expression Pattern | down-regulated |
| Function Description | NLC1-C, also known as long intergenic non-protein-coding RNA162 (LINC00162), was down-regulated in the cytoplasm and accumulated in the nucleus of spermatogonia and primary spermatocytes in the testes of infertile men with mixed patterns of MA compared with normal control. The accumulation of NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin. |
| Pubmed ID | 26539909 |
| Year | 2015 |
| Title | Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. |
External Links
| Links for NLC1-C | GenBank HGNC NONCODE |
| Links for testicular embryonal carcinoma | OMIM COSMIC |