Basic Information
| LncRNA/CircRNA Name | NKX2-1-AS1 |
| Synonyms | NA |
| Region | GRCh38_14:36519278-36523016 |
| Ensemble | ENSG00000253563 |
| Refseq | NR_103710 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, RNAi, Microarray, other |
| Sample | lung carcinoma tissues and cell line (NCI-H441) |
| Expression Pattern | up-regulated |
| Function Description | Loss-and-gain of function experiments showed that NKX2-1-AS1 does not regulate NKX2-1 expression, or nearby genes, but controls genes in trans. Genes up-regulated by NKX2-1-AS1-knockdown belong to cell adhesion and PD-L1/PD-1 checkpoint pathways. NKX2-1-AS1 negatively regulates endogenous CD274/PD-L1, a known target of NKX2-1, and the transcriptional activity of -1kb-CD274 promoter-reporter construct. Furthermore, NKX2-1-AS1 interferes with NKX2-1 protein binding to the CD274-promoter, likely by NKX2-1 protein-NKX2-1-AS1 interactions. Finally, NKX2-1-AS1 negatively regulates cell migration and wound healing, but not proliferation or apoptosis. |
| Pubmed ID | 30258080 |
| Year | 2018 |
| Title | NKX2-1-AS1 Negatively Regulates CD274/PD-L1, Cell-Cell Interaction Genes, and Limits Human Lung Carcinoma Cell Migration |
External Links
| Links for NKX2-1-AS1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |