Basic Information
| LncRNA/CircRNA Name | NKILA |
| Synonyms | AK056098 |
| Region | GRCh38_20:57710183-57712780 |
| Ensemble | ENSG00000278709 |
| Refseq | NR_131157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal cancer |
| ICD-0-3 | C32 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | laryngeal cancer tissues, cell lines (HEp-2 and TU212) |
| Expression Pattern | down-regulated |
| Function Description | We demonstrated a low NKILA expression in laryngeal cancer and its correlation with shorter overall survival in patients with laryngeal cancer. NKILA serves as a tumor suppressor in laryngeal cancer by suppressing laryngeal cancer cell viability and migration, whereas promoting cell apoptosis; NKILA knockdown reverses the cytotoxicity of X-ray radiation on laryngeal cancer cells through combining with NF-kB: IkB complex to inhibit IkB phosphorylation, inhibit p65 nuclear translocation, and finally inhibit NF-kB activation. NF-kB binds to the promoter region of NKILA to activate its transcriptional activity, upregulated NKILA then inhibits IkB phosphorylation and NF-kB activation, thus forming a negative feedback loop to sensitize laryngeal cancer cell to X-ray radiation. |
| Pubmed ID | 29573243 |
| Year | 2018 |
| Title | lncRNA-NKILA/NF-kB feedback loop modulates laryngeal cancer cell proliferation, invasion, and radioresistance. |
External Links
| Links for NKILA | GenBank HGNC NONCODE |
| Links for laryngeal cancer | OMIM COSMIC |