Basic Information
| LncRNA/CircRNA Name | NKILA |
| Synonyms | AK056098 |
| Region | GRCh38_20:57710183-57712780 |
| Ensemble | ENSG00000278709 |
| Refseq | NR_131157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, other |
| Sample | NPC tissues and cell lines (SUNE-1) |
| Expression Pattern | down-regulated |
| Function Description | Low NKILA expression was correlated with unfavorable clinicopathological features and predicted poor survival outcome in NPC patients. After adjusting for potential confounders, low expression of NKILA was confirmed to be an independent prognostic factor correlated with poor survival outcomes. Furthermore, we found that NKILA overexpression in high-metastatic-potential NPC cells repressed motile behavior and impaired the metastatic capacity in vitro and in vivo. In contrast, RNAi-mediated NKILA depletion increased the invasive motility of cells with lower metastatic potential. Further experiments demonstrated that NKILA regulated the metastasis of NPC through the NF-?B pathway. Taken together, NKILA plays vital roles in the pathogenesis of NPC. |
| Pubmed ID | 31430288 |
| Year | 2019 |
| Title | NKILA Represses Nasopharyngeal Carcinoma Carcinogenesis and Metastasis by NF-?B Pathway Inhibition |
External Links
| Links for NKILA | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |