Basic Information
| LncRNA/CircRNA Name | NKILA |
| Synonyms | NA |
| Region | GRCh38_20:57710183-57712780 |
| Ensemble | ENSG00000278709 |
| Refseq | NR_131157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | rectal cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | rectal cancer tissues, cell lines (SW837, HR8348, SW1463, FHC) |
| Expression Pattern | down-regulated |
| Function Description | The results suggested NKILA expression was decreased in rectal cancer tissues and cells, and correlated with clinical stage, T classification, N classification and M classification. NKILA low-expression was an independent poor prognostic factor in rectal cancer patients. NKILA-inhibited rectal cancer cell proliferation, migration, and invasion via suppressing NF-?B signaling. |
| Pubmed ID | 30171719 |
| Year | 2018 |
| Title | LncRNA NKILA correlates with the malignant status and serves as a tumor-suppressive role in rectal cancer. |
External Links
| Links for NKILA | GenBank HGNC NONCODE |
| Links for rectal cancer | OMIM COSMIC |