Basic Information
| LncRNA/CircRNA Name | NKILA |
| Synonyms | NA |
| Region | GRCh38_20:57710183-57712780 |
| Ensemble | ENSG00000278709 |
| Refseq | NR_131157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | OS tissues and peri-cancer tissues ,normal bone cell line Hfob1.19 ,OS cell lines ( KHOS/NP, U2OS MG63 and Saos2) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of NKILA in osteosarcoma tissues was significantly lower than that in adjacent tissues, and was related to tumor size, Enneking stage, and metastasis.Transfection of the NKILA overexpression plasmid in Saos2 cells reduced cell proliferation, invasion and migration.NKILA knockdown downregulated the expressions of p65 and E-cadherin, but strikingly increased Snail expression. p65 could bind to NKILA. Additionally, JSH was found to reverse the inhibitory effect of NKILA on cell migration and proliferation. |
| Pubmed ID | 31173281 |
| Year | 2019 |
| Title | LncRNA NKILA Inhibits Invasion and Migration of Osteosarcoma Cells via NF-?B/Snail Signaling Pathway |
External Links
| Links for NKILA | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |