Basic Information
| LncRNA/CircRNA Name | BC040587 |
| Synonyms | LINC00901, LSAMP-AS4, TCONS_00005428 |
| Region | GRCh38_3:116921431-116932238 |
| Ensemble | ENSG00000242385 |
| Refseq | NR_121607 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, FISH etc. |
| Sample | osteosarcoma tissues, cell lines (U2OS, SAOS-2, HOS etc.) |
| Expression Pattern | down-regulated |
| Function Description | The osteo3q13.31 genes LOC285194, BC040587, and LSAMP commonly show loss of expression in primary osteosarcoma samples and cell lines. Depleting either LSAMP or LOC285194 promoted proliferation of normal osteoblasts by regulation of apoptotic and cell-cycle transcripts and also VEGF receptor 1. Moreover, genetic deletions of LOC285194 or BC040587 were also associated with poor survival of osteosarcoma patients. |
| Pubmed ID | 20048075 |
| Year | 2010 |
| Title | Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. |
External Links
| Links for BC040587 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |