Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MDAMB-468, MCF-7, T47D and BT-547) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA NEAT1 was highly expressed in BC tissue, and the expression was also closely related to the tumor size and lymph node metastasis. MTT and Wound Healing assays showed that suppression of lncRNA NEAT1 could lead to decreased proliferation and metastasis in BC cell lines. Western blot also showed that B-catenin and N-cad were decreased while E-cad was increased after lncRNA NEAT1 being suppressed. |
| Pubmed ID | 28338194 |
| Year | 2017 |
| Title | lncRNA NEAT1 is closely related with progression of breast cancer via promoting proliferation and EMT. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |