Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc. |
| Sample | lung tissues, cell lines (A549, SPC-A1, H1299, 95D, SK-MES-1, NCI-H520) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 was highly expressed in NSCLC,and high NEAT1 expression was associated with a shorter overall survival.NEAT1 promoted NSCLC cell growth and affected the cell cycle process in vitro. Furthermore, NEAT1 was observed to bind hsa-miR-377-3p, functioning as a competing endogenous RNA, which resulted in de-repression of its target gene E2F transcription factor 3 (E2F3). E2F3, as an oncogene, may promote NSCLC progression.These results suggested that NEAT1 may promote the development of NSCLC through the miR-377-3p-E2F3 pathway. |
| Pubmed ID | 29085511 |
| Year | 2017 |
| Title | Long non-coding RNA NEAT1 regulates E2F3 expression by competitively binding to miR-377 in non-small cell lung cancer |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |